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���w��TOP TOP������ƌ����̃T�|�[�g�����w�ȍu����̋L�^ ���w�ȍu����̋L�^ 2016 ��2016.06.30�@�@Ying-Duo Gao �搶 �u���� ��2016.06.30�@�@Ying-Duo Gao �搶 �u���� �����F 2016�N 6��30���i�؁j15:00-16:30 �u�t�F Dr. Ying-Duo Gao (�� �n��) �@�@�@�@ (Structural Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA) ����F �uComputer-Aided Drug Design in Drug Discovery�v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j �u���v�|�F     Computer-aided drug design has become an integral part of the drug discovery process. This talk will present two stories relaying general ideas on using structure-based design and computer modeling to accelerate the drug discovery process. The first story is about identifying potent and selective lead compounds for the NPY Y5 program in collaboration with Banyu Pharmaceuticals; the second one shows the use of structure-based design leading to the discovery of Omarigliptin, a DPP-4 inhibitor for the treatment of type &#8545; diabetes. ��2016.03.11�@�@Sylvette CHASSEROT-GOLAZ �搶 �u���� �����F2016�N03��11���i���j10:30-12:00 �u�t�F Dr. Sylvette CHASSEROT-GOLAZ CR1 INSERM, Institut des Neurosciences Cellulaires et Int&#233;gratives (INCI),CNRS UPR3212 - Universit&#233; de Strasbourg ����F"Implication of Annexin A2 in exocytotic site formation" �ꏊ�F���ʍu�`��2���� 102�� �u���v�|�F �����炩�炲�����������B --> ��2016.02.12�@�@��_�c �~�q �搶 �u���� ��2016.02.12�@�@��_�c �~�q �搶 �u���� �����F 2016�N02��12���i���j13:00-14:00 �u�t�F ��_�c �~�q �搶 �@�@�@�@�i���s��w���w�������j ����F �u�זE������ς����ԑ��ݍ�p�𐧌䂷�钆���q�̑n���v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j ��2016.02.05�@�@���� ���j �搶 �u���� ��2016.02.05�@�@���� ���j �搶 �u���� �����F 2016�N02��05���i���j16:40-17:40 �u�t�F ���� ���j �搶 �@�@�@�@�i������w��w�@�H�w�n�����ȉ��w�����H�w��U�j ����F �u���ȑg�D���ɂ��@�\�ޗ����‚���v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j 2015 ��2015.11.24�@�@C&#233;line Douat �搶 �u���� ��2015.11.24�@�@C&#233;line Douat �搶 �u���� �����F 2015�N 11��24���i�΁j16:00-17:00 �u�t�F Dr. C&#233;line Douat �@�@�@�@ (University of Bordeaux 1, European Institute of Chemistry and Biology) ����F �uUrea-Based Foldamers: from structure to function�v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j �u���v�|�F     Bioinspired urea-based foldamers are artificial oligomers that are composed of ethylene diamine units connected by urea linkages. This urea backbone offers the possibility to elaborate functional mimetics of a-helical polypeptides. Over the last 10 years intense efforts of research have been devoted in the understanding of the folding rules of these oligoureas, opening now avenues to address the question of function of these helical architectures. This presentation will highlight the principles in the design of urea-based foldamers, the recent progresses in their preparation and their intended functions. �˃|�X�^�[ ��2015.08.03�@�@�{�c ���� �搶 �u���� ��2015.08.03�@�@�{�c ���� �搶 �u���� �����F 2015�N08��03���i���j15:00-16:00 �u�t�F �{�c ���� �搶 �@�@�@�@����w ���_�����i����w�Y�ƉȊw�������A���ւ������j ����F �u�Q��点��̖ʏW���̂ɂ�����L�����e�B�����i�A�L�������q�̃L�����������j�v �ꏊ�F ���w��1����4�K ���w���K���i422���j ��2015.07.10�@�@�J�� �� �搶 �u���� ��2015.07.10�@�@�J�� �� �搶 �u���� �����F 2015�N07��10���i���j16:30-18:00 �u�t�F �J�� �� �搶 �@�@�@�@�i�k�C����w��w�@ ��[�����Ȋw�����@�@�����j ����F �u�L���������@�Ő������������E���E�y�v�`�h�̗��̍\��������v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j �u���v�|�F �@���̔z�u�◧�̔z���͕��q�̐��������┽�������x�z���鐫���ł����A���̂悤�ȗ��̍\���̉�͂�n�t���ɂčs�����Ƃ͍���ł��B�����Ŗ{�����ł́A�ԊO�~��F���Ƃ��������@����g���A�e�핪�q�̗��̔z�u�◧�̔z�����ȕւ������x�Ɍ��肷����@�_�������܂����B�{�����Ŗ��炩�ɂ����e��̐������������E���E�y�v�`�h�₻�̗މ��̂̏ڍׂȍ\�������́A�V���ȗL�@���w�␶���N�������̔��W�ɂ�������ƍl���Ă���A�\����݂͂̂ɗ��܂�Ȃ��������Љ��\��ł��B ��2015.06.24�@�@Mike Schmidt �搶 �u���� ��2015.06.24�@�@Mike Schmidt �搶 �u���� �����F2015�N06��24���i���j17:00-18:30 �u�t�F Dr. Michael W. Schmidt Department of Chemistry, Iowa State University, USA ����F"The decomposition of hydrazine in the gas phase and over an Iridium catalyst" �ꏊ�F���w��1���قS�K ���w���u�`���i415���j �u���v�|�F �����炩�炲�����������B ��2015.05.15�@�@���J �z�� �搶 �����`�����Z�~�i�[ ��2015.05.15�@�@���J �z�� �搶 �����`�����Z�~�i�[ �����F2015�N05��15���i���j12:15-13:00 �u�t�F ���J �z�� �搶 �X�g���X�u�[����w�@���� ����F"Search for the most 'primitive' membranes through molecular fossils"�`���q���΂��炳����A���̖��̌��c�Ƃ́H�` �ꏊ�F�A�J�v���� 2F 201���� �u���v�|�F �����炩�炲�����������B ��2015.02.17�@�@Marie-Claire Lett �搶 �u���� ��2015.02.17�@�@Marie-Claire Lett �搶 �u���� �����F�@2015�N 2��17���i�΁j17:00-18:30 �u�t�F�@Marie-Claire Lett �搶 �@�@�@�@�@�X�g���X�u�[����w�����E������w��يْ��A���͔������w�E���Ԋw ����F�@Microbial communities in nutrients poor environments: bacterial diversity�@�@�@�@�@and survival strategies �ꏊ�F�@���w�� 1���� 4�K ���w���u�`���i415���j �u���v�|�F     Various microorganisms, including bacteria, yeasts, fungi and algae are able to survive in polluted and/or nutrients poor (oligotrophic) environments, despite the inhospitable conditions. They develop different strategies to overcome the harshness of the environment. We explored the prokaryotic diversity in acid mine drainages, characterized by low pH, high levels of toxic metals and metalloids, such as arsenic, and low concentration of organic matter. The application of novel cultures strategies revealed a much higher diversity than previously described in investigations based on classic culture methods as well as on culture independent approaches. Our work led also to the isolation of bacteria involved in organic matter recycling in these nutrient poor ecosystems and showed that some of them could be a reservoir for genes with potential biotechnologies properties. On the other hand we studied the bacterial strategies used for the colonization of nutrients poor environments. Six bacterial strains, isolated from industrial ultra pure water systems, were grown in single- and multi-species consortia. 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ChemBioChem 2012, 13, 1232. 2) Aoki, S.; Matsuo, Y.; Ogura, S.; Ohwada, H.; Hisamatsu, Y.; Moromizato, S.; Shiro, M.; Kitamura, M. Inorg. Chem. 2011, 50, 806. 3) Hisamatsu, Y.; Aoki, S. Eur. J. Inorg. Chem. 2011, 5360. 4) Moromizato, S.; Hisamatsu, Y.; Suzuki, T.; Matsuo, Y.; Abe, R.; Aoki, S. Inorg. Chem. 2012, 51, 12697. 5) Nakagawa, A.; Hisamatsu, Y.; Moromizato, S.; Kohno, M.; Aoki, S. Inorg. 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Guillain-Barré syndrome. N Engl J Med 2012. Yuki Guillain-Barré syndrome and anti-ganglioside antibodies: a clinician-scientist's journey. Proc Jpn Acad Ser B Phys Biol Sci. 2012 ��2013.09.02�@�@���� �M�� �搶 �u���� ��2013.09.02�@�@���� �M�� �搶 �u���� �����F 2013�N09��02���i���j16:30-18:00 �u�t�F ���� �M�� �搶 �@�@�@�@�i���k��w���������Ȋw�������j ����F �u���̂Ɏg���A���̂�^����@�\�����q�J���v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j �u���v�|�F �@���̂́A�������f�B�A�Ƃ����@�\�����q�̏W�c�ł���B��X�́A���̒��̍זE����^���p�N�����璅�z�𓾁A�@�\�����q���J�����Ă���B�u���̂Ɏg���v�A�u���̂�^����v���R���Z�v�g�ɓW�J���Ă���ŋ߂̐��ʂɂ‚��Ĕ��\����B ��2013.08.05�@�@Teck Peng Loh �搶 �u���� ��2013.08.05�@�@Teck Peng Loh �搶 �u���� �����F2013�N08��05���i���j15:00�` �u�t�F Teck Peng Loh �搶 ��m���H��w�@���� (Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences,  Nanyang Technological University, Singapore) ����F�uNew Synthetic Methods Inspired by Natural Product Synthesis�v �ꏊ�F���w��1���قS�K ���w���u�`���i415���j �u���v�|�F �����炩�炲�����������B ��2013.02.12�@�@Catherine Schuster �搶 �u���� ��2013.02.12�@�@Catherine Schuster �搶 �u���� �����F 2013�N 2��12���i�΁j10:30-12:00 �u�t�F Dr. Catherine Schuster, PhD, HDR �@�@�@�@ (Research director from INSERM (DR INSERM), Group leader, Inserm Unit 748, University of Strasbourg, France) ����F �uHepatitis C virus &#8211;host interactions: Role of apolipoprotein E and TIP47 in the Hepatitis C virus life cycle�v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j �u���v�|�F �@Chronic viral infections caused by hepatitis C virus (HCV) are responsible for serious public health problems. Chronic HCV infection is a common cause of liver disease leading to liver cirrhosis, liver failure and hepatocellular carcinoma. Although drug therapy for HCV is associated with significantly improved clinical outcomes among infected patients, the development of effective vaccines and novel treatment options for infected patients with resistance to current therapy remain major challenges. HCV is a positive strand RNA virus which replicates continuously in the cytoplasm of infected human hepatocytes. Its life cycle is intimately linked to the lipid metabolism of the host cell. Understanding the molecular mechanisms triggering hepatitis C infection at the level of the interactions between the virus and host factors involved in lipid homeostasis is of great interest in order to propose new therapeutic avenues for HCV difficult to treat patients. We extensively studied the role apolipoprotein E and TIP47 in the HCV life cycle. The data will be presented. �˃|�X�^�[ ��2013.02.07�@�@���� �U��Y �搶 �u���� ��2013.02.07�@�@���� �U��Y �搶 �u���� �����F 2013�N02��07���i�؁j16:00-17:30 �u�t�F ���� �U��Y �搶 �@�@�@�@�i(��)�����w�������@�Љ�m�n������ �C�m�x�[�V�������i�Z���^�[ ���ʏ��ٌ������j ����F �u�l�H�������Ɖ��w�̉��v �@�@�@�@�@�@�������̑��i�K�@���z�̌��Ɛ�����_�f���ł��� �@�@�@�@�@�@�@�@�@�@�@�@�@�@�@�@�@�@�@ ���̕��q�_ ������ ���q�̉� �ꏊ�F ���w��1����4�K���w���u�`���i415���j ���Q�l�� �����w�������@�������ʌ������z�[���y�[�W �w���A����F ���i�q 2012 ��2012.07.31�@�@��c ���F �搶 �u���� ��2012.07.31�@�@��c ���F �搶 �u���� �����F 2012�N07��31���i�΁j13:30-14:30 �u�t�F ��c ���F �搶 �@�@�@�@�i�c���`�m��w���H�w�������j ����F �u�V�O�}�g���s�[�]�ʂ����p�������������A���J���C�h�̍��������v �ꏊ�F ���w��1����4�K���w���u�`���i415���j �u���v�|�F �@�s�ē]�ʂ𔺂��V�O�}�g���s�[�]�ʂ́A���������V�R���̍����ɂ����Ă���߂ėL�p�Ȕ����ł���B�{�u���ł͐V�K�V�O�}�g���s�[�]�ʔ����i�J�X�P�[�h�^���d�]�ʁA�I���g�A�~�h�^�P��]�ʂȂǁj�̊J���ƁA�{�����𗘗p�������������A���J���C�h�ށi�}�C�Z�X�e���V���A�A�Q���X�^�`���A�u���b�\�l�`���A�J�C�j���_�Ȃǁj�̑S���������ɂ‚��āA�ŐV�̐��ʂ��q�ׂ�B ��2012.05.28�@�@Tony James �搶 �u���� ��2012.05.28�@�@Tony James �搶 �u���� �����F2012�N05��28���i���j15:30-16:30 �u�t�F Tony James �搶 �p���o�[�X��w�A���w�ȁ@���� (Department of Chemistry, Bath University, UK) ����F�uSENSING FOR HEALTH USING BORONIC ACIDS�v �ꏊ�F���w��1���قS�K ���w���u�`���i415���j �u���v�|�F �����炩�炲�����������B ��2012.01.19�@�@V. Ramamurthy �搶 �u���� ��2012.01.19�@�@V. Ramamurthy �搶 �u���� �����F 2012�N 1��19���i�؁j14:00-15:00�� �u�t�F V. Ramamurthy �搶 �@�@�@�@�č��}�C�A�~��w�@�����A�A�����J���w��Langmuir����Editor ����F �uChemistry in Cages and Cavities: Solid State Chiral Photochemistry�v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j �u���v�|�F �@For centuries, geologists knew of natural zeolites as minerals. For decades, synthetic- and industrial chemists knew them as adsorbents and catalysts. They have been explored in everyday laboratory chemistry only for the last two decades. Commercially available zeolites contain a large number of cations that could be utilized to orient molecules within the well-defined, confined spaces through cation-p and cation-carbonyl interactions. Use of zeolites as reaction media is ideal to the current environmentally conscious times of green chemistry. In this talk several examples of photochemical reactions in zeolites with chiral final products would be provided. Instances of asymmetric induction within zeolites achieved through supramolecular control would herald the opportunities and uncertainties in chiral photochemistry in zeolites. Elegant examples of asymmetric photochemistry in crystals that would also illustrate the unpredictable nature of photoreactions in crystals and solids would also be included. 2011 ��2011.12.22�@�@���� �Ζ� �搶 �u���� ��2011.12.22�@�@���� �Ζ� �搶 �u���� �����F 2011�N12��22���i�؁j15:00-16:30 �u�t�F ���� �Ζ� �搶 �@�@�@�@�i������w���q�זE�����w�����������j ����F �u��`�q��������ɂ�����G�s�Q�m������v �ꏊ�F ���w��1����4�K���w���u�`���i415���j �u���v�|�F �@�j����e�̂́A���K���h�ˑ����]�ʐ�����q�ł���A�W�I��`�q�Q�̔�����]�ʃ��x���Ő��䂵�Ă���B�ߔN�j����e�̂�p�����]�ʐ���̌�������A���F�̂̃_�C�i�~�b �N�ȍ\�����߂𔺂����Ƃ����炩�ɂȂ��Ă���B����A�G�s�Q�m�������̐i�W����A���F�̂̍č\�z�̓q�X�g���^���p�N�C�������S�I�Ȗ������ʂ������Ƃ����炩�ɂȂ�‚‚���B�㔼�ł́A�����]�ʐ���ƃG�s�Q�m������̕��q�@�\�ɂ‚��āA�q�X�g���^���p�N�C�� �𒆐S�ɐ������邱�ƂŁA�G�s�Q�m���ɂ‚��Ă̗�����[�߂Ăق����B ��2011.12.16�@�@��5�� �����Ȋw���猤���Z���^�[���J�V���|�W�E�� ��2011.12.16�@�@��5�� �����Ȋw���猤���Z���^�[���J�V���|�W�E�� �����F 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�@�L�@�����ɂ�����Y�f�\�Y�f�����`���@�̊T�O����V�����u�N���X�J�b�v�����O�����v��2010�N�x�̃m�[�x�����w�܂ɑI�΂ꂽ�B���̂�����؃J�b�v�����O�����ɂ����A�_��A�t���A�L�@EL �Ȃǂ̋@�\�����q�⍂���q�ޗ��̍�����ŋ߂̌����̓����Ȃǂ��������B ��2011.10.20�@�@��z �T�� �搶 �u���� �����F 2011�N10��20���i�؁j15:30-16:30 �u�t�F ��z �T�� �搶 �@�@�@�@�i������w��w�@���w�n�����ȉ��w��U�����j ����F �u����ON�|OFF���镨����n��v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j �u���v�|�F �@���ɉ������č\���╨�����ω����镨���́A�����]�ڕ������邢�͌����ϊ��ޗ��ȂǂƌĂ΂�A������ɂ����Ċw�p�I�������Ȃ����ƂƂƂ��ɁA���L�^���f�B�A�̍ޗ��Ƃ��čL���p�����Ă��܂��B ��X�́A����ON �|OFF���鎥�΂�A���ŋ����I��ԂƔ����̓I��Ԃ�ON�|OFF��������_�������쐻���Ă��܂����B �Ő�[�̉��w����g����ƁA����܂łɂ͑z�����‚��Ȃ����������镨���� �n�肾�����Ƃ��ł������ł��B �{�u���ł́A�����Ő�[�̌����]�ڕ����Ɋւ��ďЉ�܂��B ��2011.09.29�@�@Guido Clever �搶 �u���� �����F 2011�N9��29���i�؁j15:00-16:30 �u�t�F Guido Clever �搶 �@�@�@�@�h�C�c�E�Q�b�e�B���Q����w�AJunior Professor �@�@�@�@�iInorg. Chem. Dept., Georg-August-Universität Göttingen, Germany�j ����F �uFunctional Coordination Cages: �@�@�@�@�@Metal Stacking, Allosteric Ion Binding and Structural Control�v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j �u���v�|�F    Supramolecular coordination cages promise to find application as new tailor-made functional materials. Furthermore, they can be used as selective sensors or carriers for guest molecules. We recently prepared a series of new cages quantitatively in solution (as characterized by NMR, DOSY, ESI-MS and X-Ray). In these cages of composition [M2Ligand4]4+ the two Pd(II) or Pt(II) centers are surrounded by four rigid and concave bis-monodentate pyridyl-donor ligands. Due to their position and charge, the metals can act as anchors for the quantitative binding of bis-anionic guest molecules of appropriate size. Based on these findings, we developed a new method for making pH-switchable rotaxanes and a system capable of light-initiated crystallization. Furthermore, we used our coordination cage to encapsulate multimetal-compounds such as polyoxometallates and linear stacks of square-planar coordinated platinum complexes (Magnus�f Salt) that may find application in catalysis or material sciences.    Recently, we developed a new cage design using simple organic ligands based on the dibenzosuberone scaffold and square-planar coordinated metal ions such as Pd(II). Depending on the ligand derivative and experimental conditions, either monomeric or interpenetrated dimeric cages are formed quantitatively in solution and the solid state. The dimeric form was found to show positive homotropic, allosteric and selective binding of halide ions which was studied by UV- and NMR-spectroscopy, ESI mass spectrometry and X-ray crystallography. Addition of two equivalents of chloride ions two this dimer resulted in the selective binding of one BF4- and two Cl- ions sitting in specific positions inside the supramolecular aggregate. The monomeric forms are currently studied for their propensity to undergo endohedral functionalization. �����̏ڍׂɂ‚��ẮAClever�搶�̌�������Web�y�[�W�����Q�Ƃ������� ��2011.01.27�@�@���J ���F �搶 �u���� �����F 2011�N1��27���i�؁j �u�t�F ���J ���F �搶 �@�@�@�@�i������w��w�@���w�n�����ȉ��w��U�����j ����F �u�����q�������w�̐V�W�J�F�z��E��ԁE���[�V�����̐����ڎw���āv �ꏊ�F ���w��1����4�K ���w���u�`���i415���j 2010 ��2010.12.10�@�@Gilles Guichard �搶 �u���� �����F 2010�N12��10���i���j15:30-16:30 �u�t�F Gilles Guichard �搶 �@�@�@�@�{���h�[����w�A���[���b�p���w�E�����w������ �@�@�@�@�iEuropean Institute of Chemistry and Biology, University of Bordeaux 1�j ����F �uFolding and Assembly of Bioinspired Urea Oligomers�v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j �u���v�|�F �@Foldamers are discrete artificial oligomers with predictable and well-characterized folding patterns akin to naturally occurring helices, turns and linear strands. Selecting the appropriate building units and deciphering the associated �efolding codes�f, are determining steps towards the elaboration of discrete oligomers with defined folding patterns. Over the last 8 years, we have shown that the urea backbone is of practical value to elaborate functional mimetics of ��-helical polypeptides. This presentation will highlight rules and principles in urea foldamer design and will provide selected examples of our recent progresses in this area. ��2010.12.08�@�@Per Jensen ���� �u���� �����F 2010�N12��8���i���j17:15-18:15 �u�t�F Per Jensen ���� �@�@�@�@�h�C�c�E���b�p�[�^�[����w�A�������w�E���_���w�@���� �@�@�@�@�iPhysical and Theoretical Chemistry, University of Wuppertal, Germany�j ����F �uTorsional Splittings and Anomalous Intensities in HSOH�v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j �u���v�|�F �@Oxadisulfane HSOH can be considered a prototype skew-chain molecule with two different internal rotors; it is the first molecule of this type to be characterized spectroscopically at high resolution. The torsional motion (which has the SH moiety rotating about the SO bond relative to the OH moiety) causes the molecule to tunnel between two enantiomer potential minima through barriers with maxima at the cis and trans planar configurations, respectively. The torsional motion is strongly coupled to the over-all rotation about the a principal axis which almost coincides with the SO bond, and it gives rise to torsional energy splittings that vary in a complicated manner with rotational excitation. In calculations of the torsion-rotation energy levels of HSOH by means of the program TROVE, we have rationalized and explained the torsional splitting pattern. Also, we have simulated the rotation-torsional spectra of HSOH and explained an observed intensity anomaly caused by the torsional motion. ��2010.12.06�@�@���� �_�� �搶 �u���� �����F 2010�N12��06���i���j �u�t�F ���� �_�� �搶 �@�@�@�@�i�����E�ޗ������@�\�@MANA-�i�m�O���[������@MANA�R�[�f�B�l�[�^�[�j ����F �u�ʼnt�E�ʂɂ�����i�m�\���̂��̏ꌈ��Ƌ@�\���������̍\�z�v �ꏊ�F ���w��3����2�K�@���w����c���i207-209���j ��2010.10.25�@�@Ivan Huc �搶 �u���� �����F2010�N10��25���i���j15:00-16:00 �u�t�F Ivan Huc �搶 �{���h�[����w�A���[���b�p���w�E�����w������ �iEuropean Institute of Chemistry and Biology, University of Bordeaux 1�j ����F�uFoldamers: expanding the chemical space�v �ꏊ�F���w��1���قS�K ���w���u�`���i415���j �u���v�|�F �����炩�炲�����������B ��2010.07.30�@�@��q ������ �搶 �u���� �����F 2010�N7��30���i���j �u�t�F ��q ������ �搶 �@�@�@�@�i�L����w��w�@���w�����ȉ��w��U�����j ����F �u5 fs �p���X���[�U�[��p���镪�q�U���̏u�����g������ɂ�锽���@�\�v �ꏊ�F ���w��1����4�K�@���w���u�`���i414���j ��2010.07.23�@�@�瓇 �B�� �搶 �u���� �����F 2010�N7��23���i���j15:30-17:00 �u�t�F �瓇 �B�� �搶 �@�@�@�@�i�}�g��w��w�@���������Ȋw�����ȋ����j ����F �u���q���̓`�B�𗘗p�����@�\�������q�v �ꏊ�F ���w��1����4�K ���w���u�`�� ��2010.07.14�@�@���� �� �搶 �u���� �����F 2010�N7��14���i���j �u�t�F ���� �� �搶 �@�@�@�@�i������w��w�@�������������ȍL��Ȋw��U�����j ����F �u���w�Œ��ސl�H�זE�v �ꏊ�F ���w��3����2�K�@���w����c���i209, 208���j ��2010.04.08�@�@John S. Fossey �搶 �u���� �����F 2010�N4��8���i�؁j15:30-16:30 �u�t�F John S. Fossey �搶 �@�@�@�@�i�p��Birmingham��w) ����F �uFurther adventures with boron diol interactions�v �ꏊ�F ���w��1����4�K ���w���u�`���i415���j 2009 ��2009.06.02�@�@Bishnupada Chatterjee ���� �u���� �����F2009�N6��2���i�΁j13:30-15:00 �u�t�FBishnupada Chatterjee ���� �iWest Bengal University of Technology�@���_�����j ����F�uLectins as structural probe to detect the aberrant expression of T/Tn epitopes in cancer cells �i���N�`�����g��������זE�ɂ����Ĉُ픭������T/Tn�R���̌��o�j�v �ꏊ�F���w��1����4�K ���w���u�`���i415���j 2008 ��2008.09.10�@�@Mohammed Enamullah ���� �u���� �����F 2008�N9��10���i���j13:30-17:00 �u�t�F Mohammed Enamullah ���� �@�@�@�@�iJahangirnagar University, Department of Chemistry) ����F �uNew development of Coordination and Oragnometallic Chemistry�v �ꏊ�F ���w��1����4�K ���w�ȉ��K���i422���j ��2008.06.20�@�@Mike W. Schmidt ���m �u���� �����F 2008�N6��20���i���j11:00-12:00 �u�t�F Mike W, Schmidt ���m �@�@�@�@�iIowa State University, USA) ����F �uBringing ab initio rigor to large molecular systems�v �ꏊ�F ���w��1���فi307���j ��2008.06.11�@�@�A�J�f�~�b�N�v���_�N�V���� ���C���� �u���� �����F 2008�N6��11���i���j13:00-15:00 �ꏊ�F ���w��3����2�K�@���w����c�� �@1�D �u�t�F �勖�@��q�@���m�@�i�����̐����q��w�@�A�J�f�~�b�N�v���_�N�V�����@���C�����j �@�@�@����F�u�o�N�e���A�זE�ǂƉ��w�v �@2�D �u�t�F �X�@���q�@���m�@�i�����̐����q��w�@�A�J�f�~�b�N�v���_�N�V�����@���C�����j �@�@�@����F�u��y�ȑ��Θ_�I�ʎq���w�v�Z�c�[���F���f�����j�|�e���V�����@�̔��W�I�J���Ƃ��̉��p��v ��2008.01.11�@�@�_�� �G�L �搶 �u���� �����F 2008�N1��11���i���j16:30-18:00 �u�t�F �_�� �G�L �搶 �@�@�@�@�i���������쏊�����������t�F���[�A�����_�H��w��w�@�q�������j ����F �u�o�C�I����̔��W��DNA��͋Z�p�̐i���v �ꏊ�F ���w��3����2�K�@���w����c�� 2007 ��2007.09.27�@�@�� ���g (Jianbo Wang) ���� �u���� �����F 2007�N9��27���i�؁j15:30-17:00 �u�t�F �� ���g (Jianbo Wang) ���� �@�@�@�@�i�k����w���w�ȋ����j ����F �uTransition Metal-Catalyzed Reaction of Diazo Compounds, Alkynes and Allenes�v �ꏊ�F ���w��1���ى��w���u�`���i415���j ��2007.08.10�@�@Mihkei Koel ���� �u���� �����F 2007�N8��10���i���j16:00- �u�t�F Mihkel Koel ���� �@�@�@�@�i�G�X�g�j�A�E�^���H�ȑ�w���w�� ���w�ȁ\���͉��w ��C�����j ����F �uAlternative solvents (supercritical fluids and ionic liquids) and some examples of their use�v �ꏊ�F ���w��3����2�K ��c�� �u���v�|�F �@Very often for supercritical fluids and ionic liquids the term "neoteric solvents�h have been used. These emphasize the novelty and unusual properties of the solvents. In this presentation separately the introduction to supercritical fluids and ionic liqui ds will be given with examples on different physical and chemical properties of solven ts. Supercritical fluids represent tunability of the properties of compound by its physical parameters (temperature and pressure). The most important compounds used in supercritical conditions are carbon dioxide and water, and examples will be given on use of these supercritical fluids as extraction solvents and media for preparation of nanomaterials. Ionic liquids represent a class of compounds (low temperature organic molten salts) with very similar physical properties but different chemical behavior which can be defined as chemical tunability. The easy preparation of them gives wide flexibility of these solvents. Description of ionic liquids will be given; also some methods for characterization of ionic liquids like solvatochromism will be discussed. Also in this presentation there will be discussed the relation of these solvents with green chemistry. ��2007.08.10�@�@��R ���� �搶 �u���� �����F 2007�N8��10���i���j15:00-16:00 �u�t�F ��R ���� �搶 �@�@�@�@�i�e�L�T�X�H�ȑ�w�@���w�E�������w�ȏy�����j ����F �uChemistry and Biology�v �ꏊ�F ���w��1����4�K�@���w���u�`���i415���j �u���v�|�F �@�{�Z�~�i�[�͈ȉ��̓�‚̏��g�s�b�N����Ȃ�B (1)�v���e�I�~�N�X�����ɖ𗧂ƒ^���p�N���̒�ʖ@���蓯�ʑ̂Ń��x�����ꂽ��r�I�P���ȗL�@�������Ɣ�r�I�����ŊȒP�ȕ��@��p�� ���^���p�N���̒�ʖ@���Љ��B (2)�Ώ̃W�G�X�e���̔�y�f�I���m�������𔽉� �Ώ̃W�G�X�e���̕Е��̃G�X�e����݂̂��y�f��p�����ɑI��I�ɊȒP�Ƀ��m������ ��������@ �������������̂ł���ɂ‚��ďЉ��B 2006 ��2006.12.04�@�@�k�Y �a�v �搶 �u���� �����F 2006�N12��04���i���j15:30-16:30 �u�t�F �k�Y �a�v �搶 �@�@�@�@(�Y�����v�Z�Ȋw��������劲�������A�����w�@��w�����ȋq�������j ����F �u�t���O�����g���q�O���@�ɂ��^���p�N���̕��q������ѕ��q�ԑ��ݍ�p�̉�́v �ꏊ�F ���w��1���ى��w���u�`���i415���j �u���v�|�F �t���O�����g���q�O���@�iFMO�@)�́A�^���p�N���Ȃǂ̋��啪�q�̍\���ƃv���p�e�B���ق� ab initio �N�I���e�B�Ōv�Z�ł�����@�ł���B���̕��@�͕��q���t���O�����g�ɕ������Čv�Z���邽�߁A�^���p�N�����ł̃A�~�m�_�c��Ԃ̑��ݍ�p��A�^���p�N���ƃ��K���h�̕����̂̕��q�ԑ��ݍ�p���e�A�~�m�_�c��̊�^�ɕ������ċ��߂邱�Ƃ��ł���B�����‚��̌v�Z��������āA���̉�͖@�ɂ��^���p�N���̍\���⃊�K���h�F���ɂ‚��Ăǂ̂悤�ȕ`���������邩���Љ��B ��2006.11.30�@�@Gerhard N. Schrauzer �搶 �u���� �����F 2006�N11��30���i�؁j16:00-17:00 �u�t�F Gerhard N. Schrauzer �搶 �@�@�@�@(�č��E�J���t�H���j�A�B���T���f�B�G�S��w���_�����j ����F �uThe Mechanism of Biological Nitrogen Fixation�v �ꏊ�F ���w��3���ف@209�����i2�K�j ��2006.10.13�@�@Helmut Sigel �搶 �u���� �����F 2006�N10��13���i���j16:00-17:00 �u�t�F Helmut Sigel �搶 �@�@�@�@�X�C�X�E�o�[�[����w���� �@�@�@�@(Professor of Chemistry, Basel University, Switzerland�j ����F �uAcid-Base Properties, Tautomeric Equilibria and Metal lon-Binding of Nucleobase Residues�v �ꏊ�F ���w��3���ف@209�����i2�K�j ��2006.06.28�@�@���� ����� ���m �u���� �����F 2006�N6��28���i���j17:00-18:00 �u�t�F ���� ����� ���m �@�@�@�@(Yale��w �זE�����w�j �ꏊ�F ���w��1����4�K ���w���u�`���i415�����j �u���v�|�F �@The golgi receives the entire output of newly-synthesized proteins and lipids from the ER. These are funneled through ER exit sites to the cis or entry face of the golgi apparatus. Movement through the golgi stack is accompanied by extensive post-translational modifications, mostly to the bound oligosaccharides. At the trans or exit face, they are sorted to their final destination. The mechanism underlying transport through the golgi has long been debated but is still not resolved. Though there is general agreement that COPI vesicles are involved, their precise itinerary and contents have been difficult to work out. �@COPI vesicle targeting requires tethers and SNAREs. The tethers comprise coiled-coil golgins and multi-protein complexes, regulated by rab GTPases. We have been working on COPI vesicle tethering mediated by golgins. The p115-golgin tether is the best characterized comprising giantin in COPI vesicle linked to cis-golgin GM130/GRASP in the membrane via p115. We have now identified a new tether comprising golgin-84 in the vesicle and CASP in the Golgi membrane. �@These vesicles differ compositionally from those linked by the p115- golgin tether in that they lack members of the p24 family of putative cargo receptors and contain Golgi enzymes instead of anterograde moving cargo. They bind and fuse to cis-Golgi membranes both in vitro and in vivo. Microinjected golgin-84 or CASP also inhibits the retrograde transport of Golgi enzymes. Together these data suggest that the p115-golgin tether and the golgin-84/CASP tether modulate opposite flow patterns in the Golgi stack and that golgin tethers help determine the sub-populations of COPI vesicles that operate within the Golgi apparatus. �i���{��T�v�j COPI���E�A���̐���ɂ́Agolgin�ƌĂ΂��R�C���h�R�C���^���p�N�����֗^����ƍl�����Ă���B�{�����ł́A�V�����^�C�v��golgin�ɂ��� COPI���E����@�\�𔭌��ɐ��������B����ɁA�����‚���golgin�ɂ��COPI���E���� �̉�͂��s���ACOPI���E�� ����cargo�ɂ���Ă����‚��̃O���[�v�ɕ��ނ��邱�Ƃɐ����� ���B����� �̂��Ƃ���Agolgi�̓��̗A����golgin�ɂ���Đ��䂳��Ă���”\�����������ꂽ�B ��2006.05.31�@�@�ז�v���_���� ���{���w��w����܋L�O ���w�ȍu���� �����F 2006�N5��31���i���j15:00-16:15 �u�t�F �ז� ���v �搶 �@�@�@�@(�����̐����q��w���_�����j ����F �u���w�@���w�@����v �ꏊ�F ���w��3����7�K ��u�`�� �@�@�@�@�ˍז�v���_���� ���{���w��w����܎�܂Ɋւ����w�����z�[���y�[�W�̋L��

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